In rapid prototyping, the bottleneck isn’t the machine—it’s the setup. Drawing from over a decade of CNC machining for high-stakes prototypes, this article reveals a counterintuitive strategy: designing sacrificial fixturing systems that double as part geometry. Featuring a case study from a medical device project, I break down how this approach slashed setup time by 60% and reduced material waste by 20%, offering a blueprint for engineers who need speed without compromising precision.